CASP9 polyclonal antibody
产品名称： CASP9 polyclonal antibody
英文名称： CASP9 polyclonal antibody
产品编号： PAB14669
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against recombinant CASP9.
- Immunogen:
- Recombinant protein corresponding to human CASP9.
- Host:
- Rabbit
- Reactivity:
- Dog, Gerbils, Human, Mouse, Rat
- Specificity:
- Caspase-9 immunostaining may appear diffuse or punctate. It may be localized in the cytosol, mitochondria, and nucleus. Caspase-9 staining in the nucleus is considered to be an indication of active Caspase-9. Both pro and active Caspase-9 staining may also be seen in the mitochondria. Caspase antibodies are classical tools for detecting inactive (pro) and active (cleaved) forms of the enzymes. The presence of the large or small subunits in western blots is considered to be a marker of caspase activation.
- Form:
- Liquid
- Storage Buffer:
- In serum (0.05% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:1000-1:5000)
Immunoprecipitation (1:50-1:200)
Western Blot (1:1000-1:2000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Caspases: pharmacological manipulation of cell death.
Lavrik IN, Golks A, Krammer PH.J Clin Invest. 2005 Oct;115(10):2665-72.
- 2.
- Identifying the practice characteristics of advanced practitioners in acute and critical care settings.
Woods LP.Intensive Crit Care Nurs. 1998 Dec;14(6):308-17.
- Applications
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed, paraffin-embedded human brain sections stained for Active/Cleaved CASP9 expression using CASP9 polyclonal antibody (Cat #PAB14669) at 1 : 2000. A and B. The pattern of CASP9 staining may vary between different types of neurons. Hematoxylin-eosin counterstain.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed, paraffin-embedded dog brain sections stained for Active/Cleaved CASP9 expression using CASP9 polyclonal antibody (Cat #PAB14669) at 1 : 2000. A and B. The pattern of CASP9 staining may vary between different types of neurons. Hematoxylin-eosin counterstain.
- Entrez GeneID:
- 842
- Protein Accession#:
- NP_001220
- Gene Name:
- CASP9
- Gene Alias:
- APAF-3,APAF3,CASPASE-9c,ICE-LAP6,MCH6
- Gene Description:
- caspase 9, apoptosis-related cysteine peptidase
- Omim ID:
- 602234
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two transcript variants which encode different isoforms. [provided by RefSeq
- Other Designations:
- ICE-like apoptotic protease 6,OTTHUMP00000002322,OTTHUMP00000002323,OTTHUMP00000044594,apoptotic protease MCH-6,apoptotic protease activating factor 3,caspase 9,caspase 9, apoptosis-related cysteine protease
- Interactome
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- Adenocarcinoma
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